2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Adrenergic Receptor

Adrenergic Receptor

Beta Receptor

Adrenergic Receptor

Related Products

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Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor Isoform Specific Products:

Adrenergic Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W742404
    Bopindolol-d9
    Bopindolol-d9 ((±)-Bopindolol-d9) is the deuterium labeled Bopindolol (HY-B1562). Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.
    Bopindolol-d<sub>9</sub>
  • HY-106361
    Flerobuterol
    		Agonist
    Flerobuterol is a beta-adrenoceptor agonist with antidepressant activity. Flerobuterol enhances serotonergic neurotransmission.
    Flerobuterol
  • HY-A0077AS
    Perphenazine-d8 dihydrochloride
    		Inhibitor ≥98.0%
    Perphenazine-d8 (dihydrochloride) is the deuterium labeled Perphenazine, which is a typical antipsychotic agent(5-HT, Dopamine receptor ligand).
    Perphenazine-d<sub>8</sub> dihydrochloride
  • HY-W741706
    Butopamine hydrochloride
    Butopamine hydrochloride is an orally active inotropic compound. Butopamine hydrochloride increases heart rate more than Dobutamine (HY-15746A).
    Butopamine hydrochloride
  • HY-B0452R
    Ritodrine hydrochloride (Standard)
    		Agonist
    Ritodrine (hydrochloride) (Standard) is the analytical standard of Ritodrine (hydrochloride). This product is intended for research and analytical applications. Ritodrine (DU21220) hydrochloride is a potent and orally active β-adrenergic agonist. Ritodrine hydrochloride decreases preterm delivery and uterine contraction. Ritodrine hydrochloride has the potential for the research of preterm labor.
    Ritodrine hydrochloride (Standard)
  • HY-B1392S
    Esmolol-d7 hydrochloride
    		Inhibitor
    Esmolol-d7 hydrochloride is the deuterium labeled Esmolol hydrochloride (HY-B1392). Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 Receptoraldose reductase) and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers.
    Esmolol-d<sub>7</sub> hydrochloride
  • HY-14537R
    Latrepirdine dihydrochloride (Standard)
    		Antagonist
    Latrepirdine (dihydrochloride) (Standard) is the analytical standard of Latrepirdine (dihydrochloride). This product is intended for research and analytical applications. Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.
    Latrepirdine dihydrochloride (Standard)
  • HY-B0362AR
    Phentolamine mesylate (Standard)
    		Antagonist
    Phentolamine (mesylate) (Standard) is the analytical standard of Phentolamine (mesylate). This product is intended for research and analytical applications. Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction.
    Phentolamine mesylate (Standard)
  • HY-B0409AR
    Clonidine hydrochloride (Standard)
    		Agonist
    Clonidine (hydrochloride) (Standard) is the analytical standard of Clonidine (hydrochloride). This product is intended for research and analytical applications. Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
    Clonidine hydrochloride (Standard)
  • HY-N10452
    Methyl maslinate
    		Antagonist 98.0%
    Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research.
    Methyl maslinate
  • HY-B0192R
    Alfuzosin (Standard)
    		Antagonist
    Alfuzosin (Standard) is the analytical standard of Alfuzosin. This product is intended for research and analytical applications. Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH).
    Alfuzosin (Standard)
  • HY-103093R
    Zotepine (Standard)
    		Antagonist
    Zotepine (Standard) is the analytical standard of Zotepine. This product is intended for research and analytical applications. Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo.
    Zotepine (Standard)
  • HY-12463A
    Carmoterol
    		Agonist 99.36%
    Carmoterol is a highly potent and selective long-acting β2-adrenergic receptor agonist with a pEC50 of 10.19. Carmoterol shows 53-fold higher affinity for β2-adrenergic receptors than for β1-adrenergic receptors. Carmoterol stimulates cyclic adenosine monophosphate accumulation, induces airway smooth muscle relaxation, inhibits bronchoconstriction, reduces thromboxane B2 release, and prolongs survival time. Carmoterol can be used in research related to asthma and chronic obstructive pulmonary disease (COPD).
    Carmoterol
  • HY-101355BR
    CGP 20712 A (Standard)
    		Antagonist
    CGP 20712 A (Standard) is the analytical standard of CGP 20712 A. This product is intended for research and analytical applications. CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.
    CGP 20712 A (Standard)
  • HY-W416440
    Esmolol acid hydrochloride
    		Antagonist
    Esmolol acid (ASL-8123) hydrochloride is a weak β-adrenergic receptor antagonist. Esmolol acid hydrochloride inhibits the heart rate and diastolic blood pressure response induced by Isoproterenol (HY-B0468) in a dose-dependent manner and can be used in studies of renal failure.
    Esmolol acid hydrochloride
  • HY-32126R
    1-Fluoronaphthalene (Standard)
    		Inhibitor
    1-Fluoronaphthalene (Standard) is the analytical standard of 1-Fluoronaphthalene. This product is intended for research and analytical applications. 1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake.
    1-Fluoronaphthalene (Standard)
  • HY-12720AR
    Apraclonidine hydrochloride (Standard)
    		Agonist
    Apraclonidine (hydrochloride) (Standard) is the analytical standard of Apraclonidine (hydrochloride). This product is intended for research and analytical applications. Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid.
    Apraclonidine hydrochloride (Standard)
  • HY-118141
    BMS-194449
    		Agonist
    BMS-194449 is a beta 3 receptor agonist with the Ki value of 160 nM. BMS-194449 can be used for study of obesity and non-insulin dependent diabetes.
    BMS-194449
  • HY-B1470R
    Azaperone (Standard)
    		Antagonist
    Azaperone (R-1929) (Standard) is the analytical standard of Azaperone (HY-B1470). This product is intended for research and analytical applications. Azaperone is an antagonist of dopamine D2 receptor (Dopamine D2 Receptor) and α-adrenergic receptor (AR). Azaperone reduces vasomotor tone, mean arterial pressure, hematocrit, hemoglobin concentration, and etorphine-induced duration; induces transient tachycardia followed by bradycardia, splenic uptake of red blood cells, and sedation; alters animal behaviors; and produces sedation with distinct onset and duration in foals. Azaperone is used for sedation and tranquilization in various animals to reduce stress and aggressive behaviors, and serves as a preanesthetic agent.
    Azaperone (Standard)
  • HY-103204R
    RS100329 hydrochloride (Standard)
    		Antagonist
    RS100329 hydrochloride (Standard) is the analytical standard of RS100329 hydrochloride (HY-103204). This product is intended for research and analytical applications. RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia.
    RS100329 hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Adrenergic Receptor Isoform Comparison

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